Aromatase inhibitors in men: effects and therapeutic options

VH Nutrition offers 1,500mg of male estrogen-blocking formula in every serving of two capsules. It also gives athletes the strength, power, and endurance to push through challenging workouts and reach their ideal muscle mass. Copyright © 2020 Colleluori, Chen, Turin, Vigevano, Qualls, Johnson, Mediwala, Villareal and Armamento-Villareal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Risks from Aromatization in AgingMen

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Therapeutic uses of aromatase inhibitors in men

Hydroxyl groups at positions 4, 2′, and 4′ have generally provided compounds with a greater degree of aromatase inhibition. The 1,2 double bond is necessary for activity e.g., phloretin (80) was inactive while naringenin chalcone (78) was active. Pinostrobin (5-hydroxy-7-methoxyflavanone, 61) 125 was found to be active in JEG-3 cells 125. 7-Hydroxyflavone (26) has been tested several times and has shown strong aromatase inhibition in most microsomal assay testing 123, 124, 132. 7-Hydroxyflavone (26) also exhibited strong activity in JEG-3 cells 125 and H295R adrenocortical carcinoma cells 127 but was not active using trout ovarian aromatase 128.

• Aromatase inhibitors are a type of hormone therapy drug used to treat breast cancer in women who have gone through a natural menopause (when periods stop).
• Results of these tests can give your oncologist an idea of how you’re responding to the treatment.
• Such a change might be sufficient to alter a patient’s risk category from low to moderate depending on other risk factors, therefore triggering the need for lipid-lowering treatment.

The Role of Estrogen Modulators in Male Hypogonadism and Infertility

It is often the ratio and balance of estrogen to testosterone that effects male physiology. Most commonly an aromatase inhibitor will be prescribed to restore the balance between testosterone levels and estrogen. They were developed and are still used to treat estrogen receptor positive breast cancer.

A fluorescent antibody study15 in animals showed that myomin significantly reduced the population of hepatic aromatase within 30 days. In another study,16 myomin significantly inhibited aromatase expression in in vivo ovary, ectopic endometrium, and in vitro–cultured primary ovarian granulosa cells of rats. However, this was a proof-of-concept trial that was designed to answer mechanistic questions and the sample size of this trial is larger than some other mechanistic studies (Pitteloud et al., 2005; Yialamas et al., 2007). Indeed, the findings of this trial will provide impetus for a larger trial with AI in older men. Second, we did not perform whole body magnetic resonance imaging which would have provided volumetric information regarding fat depots.

Large studies of women with early-stage, hormone receptor-positive cancers have shown that taking tamoxifen after surgery for 5 years reduces the chances of the cancer coming back by about half. Studies in men with breast cancer have been smaller, but they have also found that taking tamoxifen after surgery for early-stage breast cancer can lower the chance of the cancer coming back and improve survival. Several approaches to blocking the effects of estrogen or lowering estrogen levels are used to treat breast cancer in women. Although many of these may work in men as well, they often haven’t been studied well, if at all. In men undergoing TRT, elevated testosterone levels can lead to higher estrogen levels, causing symptoms like gynecomastia, water retention, and emotional instability.

For example, in the study by Elisaf et al, (2001), mean LDL cholesterol levels increased from 148±50 to 170±53 mg dl−1 after 16 weeks with letrozole, while the total cholesterol to HDL cholesterol ratio increased from 3.94±1.46 to 4.48±1.40 after 16 weeks. Such a change might be sufficient to alter a patient’s risk category from low to moderate depending on other risk factors, therefore triggering the need for lipid-lowering treatment. Total and LDL cholesterol levels are decreased (Grey et al, 1995) and there is a tendency for HDL cholesterol levels to be increased, although this is often marginal (Thangaraju et al, 1994; Love et al, 1994; Decensi et al, 1998; Vrbanec et al, 1998). Triglyceride levels appear to increase (Dziewulska-Bokiniec et al, 1994; Grey et al, 1995). Levels of apolipoprotein B-100 and apolipoprotein A-I are also reduced with tamoxifen (Elisaf et al, 1996). These effects are thought to be caused by the ability of tamoxifen to act as a partial agonist in some tissues.

Customers report increased energy levels and improved mood after taking the supplement, with one customer noting better sleep quality. AndrogenHacker is a resource run by me, David Becker, that teaches men how to increase their testosterone levels using principles from biohacking, auto-analytics, and unbiased science. In fact, taking Arimidex while on testosterone is a common practice to manage estrogen levels. Many of the side effects of anabolic steroids usually go away after a person stops using them. Estrogen levels should return to typical levels, and gynecomastia should be reduced.